Research progress of autophagy in viral pneumonia
10.12092/j.issn.1009-2501.2020.11.013
- Author:
Weilu WANG
1
;
Yizhun ZHU
1
;
Yicheng MAO
2
;
Yizhun ZHU
2
;
Yizhun ZHU
3
Author Information
1. Guilin Medical College
2. Department of Pharmacology, Shanghai Key Laboratory of Bioactive Small Molecules, School of Pharmacy, Fudan University
3. State Key Laboratory and School of Pharmacy for Quality Research of Traditional Chinese Medicine, Macau University of Science and Technology
- Publication Type:Journal Article
- Keywords:
Autophagy;
Targeting effects;
Viral pneumonia
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2020;25(11):1315-1320
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy, as a highly conserved process of recovery and degradation of eukaryotic components, plays an important role in cell hunger response, maintenance of normal cell activity and specific functions in lung tissue. When cells are damaged due to physiological, pathological or chemical factors, autophagosomes and lysosomes fuse to produce a large number of autophagosomes, thus inducing the initiation of autophagy process, which is beneficial to protect cells from injury. Recent studies have found that autophagy related signaling pathways are highly correlated with the occurrence and development of a variety of viral pneumonia, such as swine influenza A (H1N1) virus, highly pathogenic avian influenza virus (H5N1), severe acute respiratory syndrome (SARS), middle east respiratory syndrome (MERS) and new coronavirus pneumonia (COVID-19). This paper will introduce the five viral pneumonia that have a great impact on China and even the whole world, and elaborate the mechanism of autophagy in these disease. Hopefully it could provide theoretical basis and effective methods and means for targeted autophagy treatment of viral pneumonia.
