Research progress of melatonin and pancreatic diseases
10.12092/j.issn.1009-2501.2020.11.012
- Author:
Chenhan ZHANG
1
;
Jingyun NIE
1
;
Pengfei XIN
1
;
Chen CHAI
1
;
Chen CHAI
2
;
Bo LI
3
Author Information
1. The First Clinical Medical College of Lanzhou University
2. Department of General Surgery, The People's Hospital of Suzhou New District
3. Department of General Surgery, The First Hospital of Lanzhou University
- Publication Type:Journal Article
- Keywords:
Acute pancreatitis;
Melatonin;
Pancreatic cancer
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2020;25(11):1309-1314
- CountryChina
- Language:Chinese
-
Abstract:
Melatonin is an indoleamine secreted by the pineal gland and plays a key role in a variety of physiological activities, including the regulation of circadian rhythm, immune response, oxidative process and apoptosis. In recent years, the anti-tumor properties of melatonin have attracted more and more attention. A large number of studies have found that melatonin plays a protective role in the early process of acute pancreatitis and can inhibit the production of pancreatic adenocarcinoma cells through apoptosis; moreover, it can regulate the synthesis and secretion of pancreatic endocrine hormones through autophagy and affect the development of pancreatic endocrine tumors. Therefore, melatonin may affect the development of pancreatic disease, but the mechanism of its action on pancreatic diseases has not been fully understood. This paper reviews the research progress of melatonin and pancreatic diseases in recent years, analyzes the role of melatonin in pancreatic diseases and the therapeutic effect of melatonin combined with chemotherapy drugs on pancreatic cancer.
