Side effects of lopinavir/ritonavir for COVID-19
10.12092/j.issn.1009-2501.2020.11.009
- Author:
Haoyu SHENG
1
;
Bin QUAN
1
;
Manman LIANG
1
;
Qiongle WU
1
;
Jianghua YANG
1
Author Information
1. Department of Infectious Diseases, Yijishan Hospital, Wannan Medical College
- Publication Type:Journal Article
- Keywords:
COVID-19;
Lopinavir/ritonavir;
Side effects
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2020;25(11):1283-1287
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the regularity and characteristics of side effects of lopinavir/ritonavir for COVID-19. METHODS: The type of side effects, general information, medical history and prognosis in 61 confirmed and suspected COVID-19 patients with lopinavir/ritonavir were analyzed. RESULTS: Among the 61 patients, 41(67.21%) had lopinavir/ritonavir related side effects, mainly manifested as gastrointestinal reactions (82.93%) and liver function damage (53.66%). Old age, long course of disease and chronic gastrointestinal disease are independent risk factors for side effects. CONCLUSION: Lopinavir/ritonavir has a high incidence of side effects and can be used in COVID-19 patients under the condition of close observation of the patient's symptoms and test results. Special population should improve pharmaceutical care to ensure the safety of drug use.
