Effects of Wuzhi capsule on the pharmacokinetics of simvastatin and its metabolite simvastatin acid in rats
10.12092/j.issn.1009-2501.2020.11.005
- Author:
Qing SUN
1
;
Jianfang SUN
2
;
Qing SUN
3
;
Li LI
3
;
Huichao CHANG
3
;
Quan ZHOU
4
Author Information
1. School of Pharmacy, Zijingang Campus, Zhejiang University
2. Medical Technology Support Department of Qinhuai Medical District, General Hospital of Eastern Theater Command
3. Department of Pharmacy, Zhejiang Hospital
4. Department of Pharmacy, The Second Affiliated Hospital of Zhejiang University School of Medicine
- Publication Type:Journal Article
- Keywords:
Blood concentration;
LC-MS/MS;
Pharmacokinetics;
Simvastatin;
Simvastatin acid
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2020;25(11):1242-1249
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To develop LC-MS /MS method for simultaneous determination of simvastatin and simvastatin acid concentrations in rat plasma, and investigate the pharmacokinetic effects of Wuzhi capsule (WZC) on simvastatin and simvastatin acid concentrations in rats. METHODS: The method was based on simple liquid liquid extraction (LLE) with lovastatin as internal standard. Agilent Eclipse-C
