Inhibition of PI3K/AKT signaling pathway by sesamin and vitamin E improves left ventricular fibrosis in spontaneously hypertensive rats
10.12092/j.issn.1009-2501.2020.11.002
- Author:
Junxiu ZHANG
1
;
Jieren YANG
1
;
Shuguo ZHENG
1
;
Wei HAO
1
;
Yuanyuan SHEN
2
Author Information
1. Department of Pharmacology, Third-Grade Pharmacology Laboratory of State Administration of Traditional Chinese Medicine, Wannan Medical College
2. Department of Clinical Pharmacy, Lu'an Second People's Hospital
- Publication Type:Journal Article
- Keywords:
CTGF;
Fibrosis;
Hypertension;
PI3K/AKT;
Sesamin;
TGF-β;
Vitamin E
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2020;25(11):1214-1222
- CountryChina
- Language:Chinese
-
Abstract:
AIM: Sesamin (Ses) is one of the major lignans in sesame seeds with antihypertensive and antifibroticactivities, but its effect is weak. In this experiment, we combined vitamin E (VitE) and Ses to observe their effects on blood pressure and left ventricular fibrosis in spontaneously hypertensive rats (SHRs), and to explore its possible mechanism. METHODS: Male SHRs were randomly divided into SHRs+Ses+VitE group, SHRs+Ses group, SHRs+VitE group, and SHRs model group. Wistar-Kyoto (WKY) rats were setted as a normal control group. After 10 weeks of administration, systolic blood pressure (SBP) of rats was measured by tail cuff method, and the left ventricle was taken to calculate the organ index. Collagen deposition was observed by Masson staining, and cardiac collagen volume fraction (CVF) was analyzed. Expressions of collagen I, collagen III, transforming growth factor-β
