Research advances of mechanically sensitive ion channel Piezo1 in cardiovascular diseases
10.12092/j.issn.1009-2501.2020.12.014
- Author:
Qing YIN
1
;
Rongzeng DU
1
Author Information
1. Department of Cardiology, Affiliated Hospital of Jiangsu University
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
Hypertension;
Ion channels;
Piezo1
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2020;25(12):1414-1421
- CountryChina
- Language:Chinese
-
Abstract:
Mechanically sensitive ion channels play an important role in the cells' perception of external pressure and the growth of tissues and organs, and participate in the regulation of various cell functions. Among them, Piezo1 is a non-selective mechanically sensitive ion channel, which mainly exists in endothelial cells and vascular smooth muscle cells. The regulation of vascular function affects the progression of cardiovascular diseases such as atherosclerosis and hypertension. This article mainly reviews the role of Piezo1 in cardiovascular diseases, and provides new directions for the clinical intervention research of cardiovascular diseases.
