Mechanism of celecoxib reverses adriamycin resistance in NK/T cell lymphoma cells by Notch 1/NF-κB/STAT3 pathway
- Author:
Zhanhe PAN
1
;
Xin WANG
1
;
An SU
1
;
Peng ZHANG
1
;
Haonan JI
1
;
Xiaomei WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Adriamycin resistance; Celecoxib; NK/T cell lymphoma cells; Notch 1/NF-κB/STAT3
- From: Chinese Journal of Clinical Pharmacology and Therapeutics 2020;25(12):1330-1336
- CountryChina
- Language:Chinese
- Abstract: AIM: To observe the mechanism of celecoxib reversal adriamycin resistance in NK/T cell lymphoma cells. METHODS: SNK6 and SNK6/ADR cells were treated with celecoxib of different concentrations (10, 20, 40, 60, 80, 100 μmol/L), the growth inhibition rate of SNK6 and SNK6/ADR were measured by MTT method. The IC
