Development of software for individualizing dosage regimens of vancomycin based on population pharmacokinetics models
10.12092/j.issn.1009-2501.2021.01.005
- Author:
Xianzhong GUO
1
;
Rongfang LIN
1
;
Weiwei LIN
1
Author Information
1. Pharmacy Department of First Affiliated Hospital of Fujian Medical University
- Publication Type:Journal Article
- Keywords:
Dose individualization;
Dosing software;
Population pharmacokinetics;
Vancomycin
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2021;26(1):30-39
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To develop software for individualizing dosage regimens of vancomycin (VCM) according to the established population pharmacokinetics (PPK) models. METHODS: VCM dosing software was developed using MyEclipse, SQL Server, and JRE. The software developing schemes included requirement analysis, general design, detailed design, software coding, software test, software maintenance and software redevelopment. RESULTS: The developed software achieved the functions such as input and management of patient information, prediction of trough concentrations under various dosing regimens which could help initial dosage design, and prediction of trough concentrations more accurately based on therapeutic drug monitoring results and Bayesian method which could help dosage adjustment. The software was utilized in the interpretation of VCM serum concentration, pharmacists proposed the suggestions for adjusting dosage regimens. The rechecked serum concentrations all reached the expected target blood concentration range in the group of adopting advice. CONCLUSION: The new developed software based on our established PPK models can provide a useful tool in the clinical setting to facilitate the individualized therapy for the adult and elderly infected patients.
