Advances on pharmacogenomics of diuretics-related adverse reactions
10.12092/j.issn.1009-2501.2021.02.012
- Author:
Kai XING
1
;
Jinyu GONG
1
;
Jianquan LUO
1
;
Kai XING
2
;
Jinyu GONG
2
;
Jianquan LUO
2
Author Information
1. Department of Pharmacy, The Second Xiangya Hospital of Central South University
2. Institute of Clinical Pharmacy, Central South University
- Publication Type:Journal Article
- Keywords:
Adverse reactions;
Diuretics;
Hypertension;
Pharmacogenomics
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2021;26(2):204-212
- CountryChina
- Language:Chinese
-
Abstract:
Diuretics are the first-line drugs for the treatment of hypertension. Long-term use of diuretics often causes elevated blood sugar, electrolyte disturbances (most commonly hypokalemia), abnormal lipid metabolism (such as increased triglycerides, elevated cholesterol), increased serum uric acid levels and so on. In order to clarify the specific mechanism of the adverse reactions related to diuretics which are widely used in the treatment of hypertension, many documents have reported the pharmacogenomics research of diuretics-related adverse reactions. This review discusses the related genes and their variants of adverse reactions caused by commonly used diuretics in the treatment of hypertension in hope of providing a basis for the study of individualized use of diuretics.
