Tetrahydroxy stilbene glycoside protects mice from acetaminophen-induced liver injury: study based on metabonomics
10.12092/j.issn.1009-2501.2021.02.006
- Author:
Yan GAO
1
;
Lin LI
1
;
Lan ZHANG
1
;
Yan GAO
2
;
Juntong LI
2
;
Qinglin WU
2
;
Yan GAO
3
;
Juntong LI
4
;
Qinglin WU
4
Author Information
1. Department of Pharmacology, Xuanwu Hospital, Capital Medical University, Phase I Clinical Research Center
2. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
3. Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Yantai University
4. Science and Technology Innovation Center, Guangzhou University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Acetaminophen;
Acute liver injury;
Metabonomics;
Tetrahydroxy stilbene glycoside
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2021;26(2):161-166
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the pharmaceutical effects of tetrahydroxy stilbene glycoside (TSG) on acute liver injury induced by acetaminophen (APAP) using method of non-targeted metabonomics. METHODS: SPF C57BL/6 mice were randomly divided into the group of APAP-induced model and the group of TSG intervention groups (n=15). After intragastric administration of TSG for 7 days, the mice were injected once by APAP via intraperitoneal injection and the livers were taken 6 hours later. RESULTS: H&E staining, MDA and SOD tests showed that the injection of APAP could cause hepatic injury, but TSG could reduce the severity of liver injury. The results of metabolite detection showed that there were significant changes in ABC transporter, choline metabolism, central carbon metabolism, galactose and alanine amino acid metabolism in TSG groups compared with APAP model group. CONCLUSION: TSG protects against acute liver injury induced by APAP, mainly by improving lipid peroxidation and disorder of energy metabolism.
