Correlation between changes of intestinal flora in children with Kawasaki disease and the levels of specific transcription factors RORγt, FOXP3 and T lymphocyte subsets
10.12092/j.issn.1009-2501.2021.02.005
- Author:
Miaoyan XUAN
1
;
Zhen XU
1
Author Information
1. Department of Pediatrics, Huzhou Central Hospital, Affiliated Hospital of Huzhou University
- Publication Type:Journal Article
- Keywords:
FOXP3;
Intestinal flora;
Kawasaki disease in children;
RORγt;
T lymphocyte subsets
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2021;26(2):154-160
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the relationship between the changes of intestinal flora in children with Kawasaki disease (KD) and the specific transcription factor Rar related orphan receptor γt (RORγt), Fork head box P3 (FOXP3), and T lymphocyte subsets. METHODS: A total of 110 children with KD in our hospital from January 2018 to June 2020 were selected and divided into simple KD group (68 cases) and KD co-infection group (42 cases) according to whether they were co-infected, and 42 healthy children during the same period were selected as the control group. The changes of the three groups of intestinal flora, RORγt, FOXP3, and T lymphocyte subsets were compared, and the relationship between the intestinal flora, RORγt, FOXP3, T lymphocyte subsets and KD co-infection was analyzed. Pearson correlation was used to analyze the correlation between the intestinal flora and RORγt, FOXP3, and T lymphocyte subsets.The receiver operating characteristic (ROC) curve and the area under the ROC curve (AUC) were used to evaluate the predictive value of intestinal flora, RORγt, FOXP3, and T lymphocyte subsets for KD co-infection. RESULTS: Lactobacillus, Veillonococcus, Clostridium, FOXP3, CD3
