Advances in understanding the role of IKKβ in tumorigenesis and its inhibitors
10.12092/j.issn.1009-2501.2021.03.016
- Author:
Xuli CHEN
1
;
Jing WEI
1
;
Jiabing WANG
1
Author Information
1. Department of Pharmacy, Taizhou Municipal Hospital
- Publication Type:Journal Article
- Keywords:
Inhibitor kappa B kinaseβ;
Inhibitor kappa B kinaseβ inhibitors;
Tumorigenesis
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2021;26(3):350-360
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the role of inhibitor kappa B kinaseβ (IKKβ) in the process of tumorigenesis has gradually been elucidated. IKK is involved in tumor cell proliferation and survival by acting on multiple molecular pathways. Inhibition of IKKβ has been identified as a promising treatment for cancer. Researchers have developed a series of IKKβ inhibitors and found that they can effectively inhibit tumor growth, but no IKKβ inhibitors have been used clinically to treat cancer. We discuss progress in understanding the role of IKKβ in tumorigenesis and review the recent development of main inhibitors of IKKβ.
