Research progress on the mechanism of miRNA in intestinal ischemia-reperfusion injury

Author: Jianmin ZHANG ¹ ; Yufang LENG ¹ ; Xin LIU ¹ ; Yixing REN ¹ ; Yajing SHI ¹ ; Feng CHEN ¹ ; Yufang LENG ²
Author Information

1. The First School of Clinical Medicine, Lanzhou University
2. Department of Anesthesiology, The First Hospital of Lanzhou University
Publication Type:Journal Article
Keywords: Intestinal injury; Intestinal protection; Ischemia-reperfusion injury; MiRNA
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2021;26(3):332-340
CountryChina
Language:Chinese
Abstract: microRNA (miRNA) is a class of 19-25 nucleotide highly conserved single-stranded non-coding RNA that is widely found in plants and animals. Their biological effect is to negatively regulate target gene expression at the post-transcriptional level through complementary pairing with mRNA. Intestinal I/R injury is more common in clinical practice, and ischemia-reperfusion will cause intestinal mucosal barrier damage, and it is related to the occurrence, development, and outcome of many clinical diseases. Many studies have shown that the miRNA subtype genes miR-34a-5p, miR-351-5p, miR-682, miR-21, etc. affect the intestinal I/R injury process to some extent by regulating a series of signal transduction. Therefore, revealing the role of miRNA in intestinal I/R injury and providing a new direction for the diagnosis and treatment of I/R.