Quantification of ambrisentan in human plasma by LC-MS/MS and its pharmacokinetic application

Author: Hong MA ¹ ; Wanhui LIU ¹ ; Hong MA ² ; Jingyuan LIU ² ; Duanyun SI ² ; Yuanyuan XIA ² ; Hao JIN ³ ; Yong CHEN ³ ; Bo WANG ⁴ ; Duanyun SI ⁵ ; Yuanyuan XIA ⁵
Author Information

1. School of Pharmacy, Yantai University
2. State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research
3. Jiangsu Deyuan Pharmaceutical Co., Ltd
4. Tianjin Institute of Pharmaceutical Research Pharmaceutical Co., Ltd
5. Research Unit for Drug Metabolism, Chinese Academy of Medical Sciences
Publication Type:Journal Article
Keywords: Ambrisentan; Human plasma; LC-MS/MS; Pharmacokinetics
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2021;26(4):382-388
CountryChina
Language:Chinese
Abstract: AIM: To establish an LC-MS/MS method to determine the concentration of ambrisentan in human plasma and apply it to the study of human pharmacokinetics. METHODS: After extracting ambrisentan and internal standard from human plasma by liquid-liquid extraction, chromatographic separation was performed on a Waters Symmetry C