Disease progression model for Alzheimer's disease and its research progress
10.12092/j.issn.1009-2501.2021.06.012
- Author:
Ningyuan ZHANG
1
;
Ling XU
1
;
Hongxia LIU
1
;
Qingshan ZHENG
1
;
Xijun ZHENG
2
Author Information
1. Drug Clinical Research Center, Shanghai University of Traditional Chinese Medicine
2. Phase I Clinical Research Center, Affiliated Tumor Hospital of Zhengzhou University
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
Disease progression model;
Modeling and simulation;
Quantitative pharmacology
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2021;26(6):687-694
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease (AD) is a degenerative neurological disease with unclear pathogenesis. The disease progress/trajectory of AD patients can be adequately described by establishing quantitative pharmacological disease progression model. Integrating biomarker information into the model can provide more insight to understand the potential pathological mechanisms and facilitate the optimization of future trial design. Several empirical and semi-mechanism disease progression models have been published. This mini-review is expected to offer some references for the further AD clinical research and new drug development.
