Effects of metformin on epithelial-mesenchymal transition of rat alveolar epithelial type II cells induced by TGF-β

Author: Wei HAO ¹ ; Dongze ZUO ² ; Junxiu ZHANG ² ; Lili JIANG ² ; Ying XIONG ² ; Jieren YANG ²
Author Information

1. Kinesiology Experimental Training Center, Wannan Medical College
2. Department of Pharmacology, Wannan Medical College
Publication Type:Journal Article
Keywords: Endothelial-mesenchymal transition; Metformin; Pulmonary fibrosis; TGF-β
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2021;26(7):744-752
CountryChina
Language:Chinese
Abstract: AIM: To observe the effect of metformin (Met) on the endothelial-mesenchymal transition (EMT) of rat alveolar epithelial type II cells and its mechanism. METHODS: The RLE-6TN cells were divided into 6 groups as follows: Control group; transforming growth factor-β