Construction and application of innovation gene-edited rats and intestinal 3D organoids models in drug metabolism and pharmacokinetics
10.12092/j.issn.1009-2501.2021.08.006
- Author:
Yuanjin ZHANG
1
;
Shengbo HUANG
1
;
Jie LIU
1
;
Xin WANG
1
Author Information
1. Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University
- Publication Type:Journal Article
- Keywords:
3D organoids;
Drug metabolism and pharmacokinetics;
Drug transporter;
Drug-metabolizing enzyme;
Gene editing rat
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2021;26(8):914-922
- CountryChina
- Language:Chinese
-
Abstract:
Drug metabolism and pharmacokinetics (DMPK) are the science to study the process of drug absorption, distribution, metabolism and excretion. It is very important to evaluate the characteristics of DMPK for the early development of drugs and the later clinical precision medication. The innovative construction of DMPK models promotes the development and improvement of drug evaluation system. Based on our research results, this review summarized the latest progress and application of innovative DMPK models, focusing on the following two aspects: (1) CRISPR/Cas9 gene editing rat models, including Cyp2e1
