Research progress and thinking on the metabolism of polysaccharide drugs in vivo and the key technology of PK/PD
10.12092/j.issn.1009-2501.2021.08.002
- Author:
Hui XU
1
;
Xinyu YANG
1
;
Zhehui ZHAO
1
;
Yan WANG
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences/Peking Union Medical College
- Publication Type:Journal Article
- Keywords:
Biological activity;
Gut bacteria;
Pharmacokinetic characteristics;
PK/PD;
Polysaccharide drugs
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2021;26(8):851-862
- CountryChina
- Language:Chinese
-
Abstract:
Polysaccharide drugs are a type of safe and effective natural drug with a wide range of pharmacological activity such as anti-tumor, immunomodulation, and oxidation, and polysaccharide drugs are currently more concerned. However, since the molecular weight of the polysaccharide is quite large, most of which do not have ultraviolet absorption and fluorescent groups, which makes the qualitative and quantitative analysis of polysaccharides are relatively difficult. In addition, endogenous sugar substances may also cause certain interference to polysaccharide assay in biological samples, and therefore, in vivo metabolism and PK/PD key technologies in polysaccharide drugs have been research hotspots. This paper summarizes the relevant literature published in recent years, reviewing the biological activity and pharmacokinetics of polysaccharide drugs, proposing gut bacteria may be potential "organ" affecting metabolism and efficacy of polysaccharide drugs, and providing thoughts on gut bacteria mediating polysaccharide drugs in vivo and key technology research of PK/PD, in order to provide more scientific ideas for pharmacokinetics, pharmacological research and molecular mechanisms of polysaccharide drugs.
