Research strategies and considerations on non-clinical pharmacokinetics of nanomedicine
10.12092/j.issn.1009-2501.2021.08.001
- Author:
Shujun FU
1
;
Fanghua HUANG
1
;
Tao SUN
1
;
Qingli WANG
1
;
Jingkai GU
2
;
Wei WU
3
Author Information
1. Center for Drug Evaluation, National Medical Products Administration
2. College of Life Science, Jilin University
3. School of Pharmacy, Fudan University
- Publication Type:Journal Article
- Keywords:
Carrier material;
Encapsulated drug;
Nanomedicine;
Non-clinical pharmacokinetics;
Released drug
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2021;26(8):842-850
- CountryChina
- Language:Chinese
-
Abstract:
With the rapid development of nanotechnology, the research and development of nanomedicine has become one of the current development directions of drug innovation. The pharmacokinetic characteristics of nanomedicine are significantly different from general drugs because of the scale effect based on nanostructures, and pharmacokinetics studies of nanomedicine may be different from the general drugs. This article focuses on the research strategies and considerations on non-clinical pharmacokinetics of nanomedicine, including test agents, in vivo/in vitro assays, biological sample analysis, data evaluation and analysis etc., providing references for developers.
