Application of nalbuphine in ultrasound-guided transvaginal oocyte retrieval and its effect on embryo quality and pregnancy outcome

Xin Liu; Xuehong Zhang; Lili Zhang; Shanshan QU; Yiqing Wang; Xin Liu; Yufang Leng; Xuehong Zhang; Lili Zhang; Shanshan QU; Yiqing Wang; Yufang Leng; Mengjie Zhang; Jianqin Xie

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Application of nalbuphine in ultrasound-guided transvaginal oocyte retrieval and its effect on embryo quality and pregnancy outcome

Author: Xin LIU ¹ ; Xuehong ZHANG ¹ ; Lili ZHANG ¹ ; Shanshan QU ¹ ; Yiqing WANG ¹ ; Xin LIU ² ; Yufang LENG ² ; Xuehong ZHANG ² ; Lili ZHANG ² ; Shanshan QU ² ; Yiqing WANG ² ; Yufang LENG ³ ; Mengjie ZHANG ³ ; Jianqin XIE ⁴
Author Information

1. Reproductive Medicine Center, The First Hospital of Lanzhou University
2. The First Clinical Medical College of Lanzhou University
3. Department of Anesthesiology, The First Hospital of Lanzhou University
4. Department of Anesthesiology, The Second Hospital of Lanzhou University
Publication Type:Journal Article
Keywords: Embryo quality; In vitro fertilization-embryo transfer; Nalbuphine; Pregnancy outcome; Ultrasound-guided transvaginal oocyte retrieval
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2021;26(9):1042-1047
CountryChina
Language:Chinese
Abstract: AIM: To observe the anesthetic effect of nalbuphine used in ultrasound-guided transvaginal oocyte retrieval and its effect on embryo quality and pregnancy outcome. METHODS: Four-hundred patients who underwent ultrasound-guided transvaginal oocyte retrieval were randomly divided into two groups (n=200): nalbuphine group (N group) and control group (C group). The patients were in the bladder lithotomy position. Patients in N group were given nalbuphine 0.1 mg/kg intravenously 2 minutes before induction of anesthesia, patients in C group were given normal saline intravenously, and patients in both groups were induced with propofol 1.5 mg/kg. The patients were kept breathing spontaneously, and they were given intravenous injections of propofol (2 mg•kg