Establishment of population pharmacokinetics model of vancomycin in patients with Neutropenia

Author: Liangmo LIN ¹ ; Jian XIAO ¹ ; Liangmo LIN ² ; Xiangjun FU ² ; Lili ZHONG ² ; Hefang WANG ² ; Qiongshi WU ² ; Jian XIAO ³
Author Information

1. Central South University
2. Hainan General Hospital(Hainan Affiliated Hospital of Hainan Medical University)
3. Xiangya Hospital of Central South University
Publication Type:Journal Article
Keywords: Neutropenia; Population pharmacokinetics(PPK) model; Vancomycin
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2021;26(9):1014-1022
CountryChina
Language:Chinese
Abstract: AIM: To establish a population pharmacokinetics (PPK) model of vancomycin in patients with hematological diseases who developed neutropenia. METHODS: Patients from department of hematology with neutropenia in our hospital were taken into oue study.The patients (n=77) were performed trough and peak serum concentration of vancomycin, and their clinical data and medication information were collected. The Nonlinear mixed effect modeling approach (NONMEM) was used to establish the PPK model of those patients and model assessment and validation was carried out. Goodneess of fit plots and visual predictive check plus Bootstrap approach were used to assess validate our model. RESULTS: The model was a two compartment model, the final formulas were: clearance rate CL=6.84×(BW/70)