Research progress of dynamic regulation of lysine acetylation in heart disease
10.12092/j.issn.1009-2501.2021.10.012
- Author:
Yuan ZHAO
1
;
Qianwen NIE
1
;
Jiangyan YIN
1
;
Xuan HUAN
1
;
Meixiang TIAN
1
;
Zhengyi ZHANG
1
Author Information
1. Department of General Medicine, Lanzhou University Second Hospital
- Publication Type:Journal Article
- Keywords:
Acetyltransferase;
Deacetylase;
Heart disease;
Histone;
Lysine acetylation
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2021;26(10):1186-1192
- CountryChina
- Language:Chinese
-
Abstract:
Reversible post-translational modification of proteins is an important process in the physiological regulation of all tissues, including the heart. Lysine acetylation occurs in all organisms, including prokaryotes, and is regulated by a balance between lysine acetyltransferase (adding acetyl to the ε-amino group of lysine) and deacetylase (acetyl group that removes lysine ε-amino group). The heart is an organ rich in acetylated lysine, but the role of acetylated lysine in the heart remains to be elucidated. Therefore, in this paper, we systematically reviewed the gene list of acetyltransferase and deacetylase in mammalian genome and indicated their mRNA expression. The purpose of this study is to discover the research progress of dynamic regulation of lysine acetylation in heart disease and to provide a theoretical basis for the discovery of molecular targets.
