Effect of acute normovolemic hemodilution autologous blood transfusion on the EEG bispectral index and muscle relaxation in elderly patients undergoing orthopedic surgery
10.12092/j.issn.1009-2501.2021.10.007
- Author:
Lei YIN
1
;
Jianrong GUO
1
;
Jiaming XU
2
;
Lishuang DUAN
2
;
Hanwei WEI
2
;
Jingyi WU
3
;
Xiaoju JIN
3
Author Information
1. Department of Anesthesiology, Wuxi Second People's Hospital
2. Department of Anesthesiology, Shanghai Gongli Hospital, The Naval Military Medical University
3. Department of Critical Medicine, The First Affiliated Hospital of Wannan Medical College
- Publication Type:Journal Article
- Keywords:
Acute normovolemic hemodilution;
Autologous blood transfusion;
EEG bispectral index;
Muscle relaxant effect;
Plasma drug concentration
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2021;26(10):1153-1158
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effect of acute normovolemic hemodilution (ANH) autologous blood transfusion on the EEG bispectral index and muscle relaxation in elderly patients undergoing orthopedic surgery to explore the influence of autologous blood transfusion containing anesthetic components on the quality and safety of postoperative anesthesia recovery. METHODS: Forty patients, aged 65-75, weighing 55-80 kg, ASA grade I-II, with an estimated intraoperative blood loss of more than 600 mL, were selected for elective orthopedic surgery. The patients were randomly divided into two groups (n=20): group A was given acute normovolemic hemodilution (ANH), and the target value of Hct was 28%-30% after induction of anesthesia; group B was the control group which was given routine fluid infusion during operation without ANH. Bispectral index (BIS), TOF values and plasma concentrations of propofol and cisatracurium were measured at the beginning of autotransfusion (T
