Effects of different postpartum withdrawal time of tenofovir on hepatitis B virus markers, virology and biochemical indexes
10.12092/j.issn.1009-2501.2021.10.006
- Author:
Chengjing TAO
1
;
Jiannv HU
1
;
Xiuli BAI
1
;
Suying ZHANG
1
;
Shourong LIU
2
;
Chun ZHAO
2
;
Zhongbao ZUO
3
;
Xiaoxian CHENG
4
Author Information
1. Department of Obstetrics and Gynecology, Hangzhou Xixi Hospital, Zhejiang Chinese Medical University
2. 1st Department of Medicine, Hangzhou Xixi Hospital, Zhejiang Chinese Medical University
3. Department of Laboratory, Hangzhou Xixi Hospital, Zhejiang Chinese Medical University
4. Department of Obstetrics and Gynecology, Tonglu Maternal and Child Health Hospital
- Publication Type:Journal Article
- Keywords:
Drug withdrawal time;
Hepatitis B virus;
Tenofovir
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2021;26(10):1146-1152
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate the effect of TDF withdrawal time on changes of serum HBV-M, HBV DNA and ALT level in the mother-to-child blocking of the maternal population. METHODS: A prospective, randomized and controlled study was conducted. The 120 pregnant women with HBV who took TDF during 24 to 28 weeks of gestation were randomly divided into group A (withdrawal at delivery) and group B (withdrawal at 4 weeks postpartum), levels of HBV-M, HBV DNA, and ALT at different times were detected. The results were statistically analyzed by Wilcoxon Rank-sum test and χ
