Model informed precision dosing: China expert consensus report
- Author:
Zheng JIAO
;
Xingang LI
;
Dewei SHANG
;
Jing DONG
;
Xiaocong ZUO
;
Bing CHEN
;
Jianmin LIU
;
Yan PAN
;
Tianyan ZHOU
;
Jing ZHANG
;
Dongyang LIU
;
Lujin LI
;
Yi FANG
;
Guangli MA
;
Junjie DING
;
Wei ZHAO
;
Rui CHEN
;
Xiaoqiang XIANG
;
Yuzhu WANG
;
Jianjun GAO
;
Haitang XIE
;
Pei HU
;
Qingshan ZHENG
- Publication Type:Journal Article
- Keywords: Artificial intelligence; Clinical decision supporting system; Consensus; Modeling and simulation; Pharmacokinetics and pharmacodynamics; Physiologically based pharmacokinetics; Precision dosing
- From: Chinese Journal of Clinical Pharmacology and Therapeutics 2021;26(11):1215-1228
- CountryChina
- Language:Chinese
- Abstract: Model informed precision dosing (MIPD) is a new concept to guide precision dosing for individual patient by modeling and simulation based on the available information about the individual patient, medications and the disease. Compared to the empirical dosing, MIPD could improve the efficacy, safety, economics and adherence of the pharmacotherapy according to the individual's pathophysiology, genotyping and disease progression. This consensus report provides a brief account of the concept, methodology and implementation of MIPD as well as clinical decision supporting systems for MIPD. The status and future advancing of MIPD was also discussed to facilitate the appropriate application and development of MIPD in China.