Absorption and excretion of CT-707 in healthy male subjects studied by radioisotope tracer method
10.12092/j.issn.1009-2501.2021.12.010
- Author:
Guijuan HAN
1
;
Ji JIANG
2
;
Weiwei OUYANG
3
;
Hong LUO
4
;
Xiaojun ZHANG
4
;
Minghua WANG
5
Author Information
1. Graduate School, Guizhou Medical University of Medical Sciences
2. Clinical Pharmacology Center of Peking Union Medical College Hospital and Chinese Academy of Medical Sciences
3. Department of Oncology, the Affiliated Hospital of Guizhou Medical University/the Affiliated Cancer Hospital of Guizhou Medical University
4. Shouyao Holding (Beijing) Co., Ltd
5. Department of Nuclear Medicine, the Affiliated Hospital of Guizhou Medical University
- Publication Type:Journal Article
- Keywords:
Absorption;
Excretion;
Liquid scintillation counting;
Radioactive isotopes;
[
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2021;26(12):1407-1412
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the absorption and excretion of CT-707 in healthy male subjects. METHODS: Six healthy male subjects received a single 300 mg (120 μCi) oral dose of radio-labeled CT-707 as a suspension in a fasted state. Blood, urine and feces were collected. Radioactivity concentrations were measured by liquid scintillation counting (LSC). The pharmacokinetic parameters of total radioactivity in plasma were calculated by WinNonlin (Pharsight version 8.1) software according to the non-compartment model. The recovery rate of total radioactivity in urine and feces was calculated according to the weight and radioactivity concentration of urine and feces collected at each time interval. RESULTS: After a single 300 mg oral of radio-labeled CT-707 552 h (23 d) as a suspension in a fasted state, the mean AUC
