Research progress on bile acid metabolism mediated by uridine diphosphate glucuronic acid transferase and its endogenous and exogenous influencing factors

Shengjie Guo; Xirui Guan; Wenli Cao; Xiaoyi QI; Shengjie Guo; Xirui Guan; Wenli Cao; Sicheng Liang; Muhan LV; Guangbo GE

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Research progress on bile acid metabolism mediated by uridine diphosphate glucuronic acid transferase and its endogenous and exogenous influencing factors

Author: Shengjie GUO ¹ ; Xirui GUAN ¹ ; Wenli CAO ¹ ; Xiaoyi QI ¹ ; Shengjie GUO ² ; Xirui GUAN ² ; Wenli CAO ² ; Sicheng LIANG ² ; Muhan LV ² ; Guangbo GE ³
Author Information

1. Department of Dermatology, Affiliated Hospital of Southwest Medical University
2. Department of Gastroenterology, Affiliated hospital of Southwest Medical University
3. Institute of Interdisciplinary Intergrative Medicine Research, Shanghai University of Traditional Chinese Medicine
Publication Type:Journal Article
Keywords: Balance intervention; Bile acid; Influence factor; UDP-glucuronosyltransferases
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2022;27(1):102-107
CountryChina
Language:Chinese
Abstract: Uridine diphosphate glucuronic acid transferase (UDP-glucuronosyltransferases, UGT) is an important Ⅱmetabolic enzymes in the body. It is invovled in the metabolism of exogenous compounds, and also in endogenous substances such as bile acid metabolism and regulation. Parsing uridine diphosphate glucuronic acid transferase mediated bile acid metabolism and its influence factors can help enhance related disease treatment and prevention. Studies have shown that the interaction between UGT and bile acids is influenced by many endogenous and exogenous factors. This paper will focus on the effects of internal and exogenous factors such as nuclear receptors, genetic factors, xenobiotics and liver-related diseases on the action of UGT enzyme, and discuss the potential mechanism of bile acid balance intervention.