Bioequivalence of amlodipine besylate tablets in Chinese healthy subjects
- Author:
Rong GAO
1
;
Yazhong MA
1
;
Haixia ZHAO
1
;
Zhaoyuan WANG
1
;
Weihong ZHANG
1
;
Hailong YUAN
1
Author Information
- Publication Type:Journal Article
- Keywords: Amlodipine; Bioequivalence; Healthy volunteers; LC-MS/MS
- From: Chinese Journal of Clinical Pharmacology and Therapeutics 2022;27(1):56-62
- CountryChina
- Language:Chinese
- Abstract: AIM: To evaluate the bioequivalence of two kinds of amlodipine besylate tablets in Chinese healthy subjects under fasting and fed conditions. METHODS: Twenty-four healthy subjects were enrolled, and a random, open, single-dose, two preparations, two sequences and double-crossover design was used to give the test or reference preparations under fasting and postprandial conditions. The concentration of metformin in plasma was detected by LC-MS/MS, and the main pharmacokinetic parameters were calculated to evaluate the bioequivalence. RESULTS: In fasting state, the mean of C
