Effects of extracorporeal membrane oxygenation on pharmacokinetics and pharmacodynamics of daptomycin in critically ill patients
10.12092/j.issn.1009-2501.2022.01.006
- Author:
Linlin HU
1
;
Linlin HU
2
;
Weilan LI
2
;
Jie HE
2
;
Hua SHAO
2
;
Silu XU
3
;
Jinglu ZHANG
4
Author Information
1. Office of Clinical Trial Institution, Nanjing Zhongda Hospital, Southeast University, School of Medicine
2. Department of Pharmacy, Nanjing Zhongda Hospital, Southeast University, School of Medicine
3. Department of Pharmacy, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University
4. School of Medicine, Southeast University
- Publication Type:Journal Article
- Keywords:
Daptomycin;
Severe infection;
The extracorporeal membrane oxygenation;
The PK-PD study
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2022;27(1):39-46
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of extracorporeal membrane oxygenation (ECMO) on the pharmacokinetics/pharmacodynamics (PK/PD) of daptomycin in critically ill patients. METHODS: Twenty four patients with severe infection in our hospital were randomly selected and divided into ECMO group and non ECMO group. They were intravenously injected with daptomycin 500 mg qd. After the drug reached the stability statement, venous blood was collected at different time points before and after the infusion. The plasma drug concentration was measured and the pharmacokinetic parameters were calculated. The probability target acquisition (PTA) and the cumulative fraction response (CFR) were calculated by Monte Carlo simulation. RESULTS: After dosing, the main pharmacokinetic parameters in ECMO and non-ECMO group were calculated and listed as follows: C
