Effects of different administration methods on the pharmacokinetics and tissue distribution of ribavirin in rats
10.12092/j.issn.1009-2501.2022.01.004
- Author:
Lu GUO
1
;
Yicen HAN
1
;
Xiaoshu LIU
1
;
Jing ZHANG
1
;
Qin LANG
1
;
Tian ZHONG
1
;
Zhendong ZHONG
2
;
Yi SHI
3
;
Yong YANG
4
;
Yuan BIAN
4
Author Information
1. Department of Pulmonary and Critical Care Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China
2. Animal Experimental Center, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China
3. Sichuan Provincial Key Laboratory for Human Disease Gene Study and Department of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China
4. Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China
- Publication Type:Journal Article
- Keywords:
Acyclovir;
ESI;
HPLC-QqQ-MS;
Pharmacokinetics;
Ribavirin;
Tissue distribution
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2022;27(1):25-32
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To establish a HPLC-QqQ-MS with multiple reaction monitoring (MRM) method for pharmacokinetics and tissue distribution study of ribavirin by oral and respiratory administration. METHODS: The experiment established a high-sensitivity LC-MS analytical method for the detection of ribavirin, and the linearity, specificity, recovery, accuracy, and precision were investigated. The established methods were used to investigate the pharmacokinetics and tissue distribution of the oral and respiratory administration methods. RESULTS: The concentration of drugs in the blood through respiratory tract administration is higher, and the drug absorption is faster. Respiratory tract administration C
