Ferroptosis regulatory signaling pathway and its research progress in related diseases
10.12092/j.issn.1009-2501.2022.02.015
- Author:
Liang ZHANG
1
;
Xiaoli LI
1
;
Liang ZHANG
2
;
Xiaoli LI
2
;
Yongqun LIAO
3
;
Qinchuan XIA
3
;
Shitong ZHOU
4
Author Information
1. Department of Pharmacology, College of Pharmacy, Chongqing Medical University
2. Chongqing Key Laboratory of Drug Metabolism
3. Fuan Pharmaceutical Group Chongqing Bosen Pharmaceutical CO.LTD
4. Department of Otolaryngology Head and Neck Surgery, Chongqing General Hospital, University of Chinese Academy of Sciences
- Publication Type:Journal Article
- Keywords:
Cancer;
Ferroptosis;
Iron metabolism;
Lipid peroxidation;
Non-alcoholic fatty liver disease
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2022;27(2):227-234
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is an iron-dependent novel type of programmed cell death. The main features of ferroptosis include lipid reactive oxygen accumulation, iron accumulation and lipid peroxidation. The main mechanisms and signal pathways of ferroptosis are complex and closely related to cystine/glutamate antiporter system, glutathione peroxidase 4, ferroptosis suppressor protein 1, and dihydroorotate dehydrogenase. This review summarizes the current regulatory mechanisms of ferroptosis and discusses the research progress of ferroptosis in tumors, non-alcoholic fatty liver disease, Parkinson's disease, and congestive heart failure.
