Research progress of short-chain fatty acids in alleviating organ ischemia-reperfusion injury

Author: Xingjiao LV ¹ ; Yufang LENG ¹ ; Xiaoxia HAN ¹ ; Xiaoyu HOU ¹ ; Xuefen CAO ¹ ; Janvier NIBARUTA ¹ ; Yongqiang LIU ¹ ; Yufang LENG ²
Author Information

1. The First Clinical Medical College of Lanzhou University
2. Department of Anethesiology, The First Hospital of Lanzhou University
Publication Type:Journal Article
Keywords: Ischemia-reperfusion injury; Organ protection; Short-chain fatty acids
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2022;27(2):219-226
CountryChina
Language:Chinese
Abstract: Short-chain fatty acids (SCFAs) are organic acids with no more than 6 carbon atoms produced during the anaerobic fermentation of dietary fiber in the intestinal tract, which can regulate intestinal flora, repair intestinal mucosal barrier, and reduce intestinal injury.Ischemia-reperfusion injury (IRI) is the main cause of various diseases, and the pathological mechanisms involved are intricate, among which inflammation, oxidative stress, apoptosis and autophagy are the most common. According to current studies, SCFAs can affect the occurrence and development of IRI in various organs by regulating different cell signal transduction. In this paper, the role and mechanism of SCFAs in alleviating tissue and organ ischemia-reperfusion injury were preliminarily summarized, providing theoretical reference for clinical prevention and treatment of IRI.