Effects of Shenqi fuzheng injection on low-glucose-mediated immunosuppressive microenvironment and its mechanism of action
- Author:
Wangbo MA
1
;
Yue MA
1
;
Fangtian FAN
1
;
Yuhan ZHANG
1
;
Jingwen CHANG
1
;
Zhihua ZHOU
1
;
Wangbo MA
2
;
Yue MA
2
;
Fangtian FAN
2
;
Yuhan ZHANG
2
;
Jingwen CHANG
2
;
Zhihua ZHOU
2
Author Information
- Publication Type:Journal Article
- Keywords: Low sugar microenvironment; Shenqi fuzheng injection; Tumor infiltrating lymphocytes
- From: Chinese Journal of Clinical Pharmacology and Therapeutics 2022;27(2):136-143
- CountryChina
- Language:Chinese
- Abstract: AIM: To investigate the effect of Shenqi fuzheng injection (SFI) on tumor immunity and its preliminary molecular mechanism. METHODS: The animal model of low glucose tumor microenvironment was established by B16-PKM2-OE; the level of interleukin-2(IL-2) and interferon-γ(IFN-γ), CD40L and transforming growth factor-β1(TGF-β1) were detected by ELISA kit; the expressions of glucose transporter-1 (Glut-1) and key enzymes of glycolysis ( HK, PFK and PK ) in CD4
