Research progress on the relationship between thyroid hormone and idiopathic pulmonary fibrosis

Author: Jifang WEI ¹ ; Hongmei YUE ¹ ; Nanyu LIU ¹ ; Peipei SONG ¹ ; Yingying XIE ¹ ; Jiaqi WANG ¹ ; Yaqian WEI ¹ ; Hongmei YUE ²
Author Information

1. The First Clinical Medical College of Lanzhou University
2. Department of Respiratory Medicine, the First Hospital of Lanzhou University
Publication Type:Journal Article
Keywords: Glucose metabolism; Idiopathic pulmonary fibrosis; Inflammation; Mitochondrion; Thyroid hormone
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2022;27(3):307-313
CountryChina
Language:Chinese
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease with unknown etiology, which is characterized by scarring of lung parenchyma, leading to reduced quality of life and premature death. At present, some studies have confirmed that hypothyroidism (HT) may play a role in the development of fibrosis. Many animal experiments have proved that thyroid hormone (TH) can inhibit pulmonary fibrosis by regulating glucose metabolism, improving mitochondrial function and inhibiting inflammation. This paper summarizes the correlation between TH and IPF, and deeply understands the relationship between TH and IPF, in order to have new treatment strategies for IPF in the future.