Effects of preoperative dezocine patient-controlled analgesia pump on stress response and cognitive function in elderly patients with lower extremity fractures
10.12092/j.issn.1009-2501.2022.03.009
- Author:
Yongliang LI
1
;
Haiyan LIN
1
;
Yilong DONG
1
;
Lingling ZHANG
2
Author Information
1. The Third Affiliated Hospital of Wenzhou Medical University
2. Ninghai Hospital of traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Analgesia pump;
Cognitive function;
Elderly lower extremity fractures;
Self-controlled;
Stress response
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2022;27(3):302-306
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effects of preoperative application of dezocine patient-controlled analgesia pump on stress response and cognitive function in elderly patients with lower extremity fractures. METHODS: A total of 80 elderly patients with lower extremity fractures who were treated from November 2018 to June 2020 were selected and randomly divided into a control group and a study group, 40 cases in each. The control group was not given a patient-controlled analgesia pump before anesthesia, and the study group was given intravenous analgesia with a dezocine patient-controlled analgesia pump before surgery. The postoperative stress response, cognitive function and safety were compared between the two groups.RESULTS: There were no significant differences in cognitive function MMSE score, stress response index (cortisol, epinephrine) levels, and inflammatory factors (IL-6, TNF-α) levels between the two groups before intervention (P>0.05). Compared with the indexes after operation, the MMSE scores of the study group at 12 h, 24 h and 3 days after operation were higher than those in the control group (P<0.05); The levels of cortisol, epinephrine, IL-6 and TNF-α in the study group were lower than those in the control group at 12 h and 24 h after operation (P<0.05); At the same time, the incidences of respiratory depression, urinary retention and nausea and vomiting in the study group were significantly lower than those in the control group (P<0.05).CONCLUSION: Preoperative application of dezocine patient-controlled analgesia pump in elderly patients with lower extremity fracture can significantly reduce postoperative stress response, reduce inflammatory response, and improve postoperative cognitive function, which is worthy of clinical application.
