Application of chronopharmacology in the hypertension treatment
10.12092/j.issn.1009-2501.2022.04.010
- Author:
Ningzhi ZHANG
1
;
Minna TANG
1
;
Yongqiao ZHANG
1
;
Sisi NING
1
;
Zhaoqiang CUI
1
;
Yuhong ZHAO
2
Author Information
1. Shanghai Institute of Cardiovascular Disease-Department of Cardiology, Zhongshan Hospital, Fudan University
2. Shanghai Changning Tianshan Traditional Chinese Medicine Hospital
- Publication Type:Journal Article
- Keywords:
Biorhythm;
Chronopharmacology;
Chronotherapy;
Hypertension;
Pharmacochronology
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2022;27(4):418-422
- CountryChina
- Language:Chinese
-
Abstract:
The human biorhythm is closely related to the blood pressure level and the effect of the antihypertensive treatment of hypertension. The human circadian biorhythm changes the therapeutic effect of antihypertensive drugs by affecting the pharmacokinetics and pharmacodynamics; at the same time, following the human blood pressure rhythm in the treatment of hypertension can reduce the risk of target organ damage and cardiovascular and cerebrovascular events. Therefore, in the treatment of hypertension, the administration time and drug dosage should be adjusted according to the pharmacochronology to obtain the best curative effect and minimal side effects, and reduce the occurrence of adverse reactions and complications.
