Research progress and application prospects of circRNA in cardiovascular diseases
10.12092/j.issn.1009-2501.2022.04.007
- Author:
Zichun CAI
1
;
Yuanzhen JIANG
1
;
Chunsheng ZHANG
1
;
Jiming LI
1
;
Jiming LI
2
Author Information
1. Department of Cardiology, Shanghai East Hospital of Clinical Medical College, Nanjing Medical University
2. Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University
- Publication Type:Journal Article
- Keywords:
Cardiovascular diseases;
CircRNAs;
RNA editing;
RNA vaccine
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2022;27(4):397-404
- CountryChina
- Language:Chinese
-
Abstract:
CircRNA is a single-stranded, covalently closed non-coding RNA, whose mechanism mainly involves sponge adsorption of micro RNA (miRNA), regulation of protein transcription and post-transcriptional levels, interaction with RNA-binding proteins and few coding proteins of circRNA. Meanwhile, because of its abundant expression, highly conserved and dynamic changes, circRNAs have promising applications such as becoming biomarkers of diseases, developing circRNA vaccines and gene editing therapies for circRNAs. Cardiovascular diseases are the leading cause of death from diseases worldwide, and existing therapeutic approaches can delay the development of heart diseases, but are still limited by the unknown pathogenesis and therapeutic targets. Many studies have reported the mechanistic link between circRNAs and cardiac diseases, therefore, this review is to explain the progress of circRNA research in cardiovascular diseases and to illustrate the three clinical applications in which circRNAs are currently involved.
