Research progress of β2 microglobulin
10.12092/j.issn.1009-2501.2022.04.006
- Author:
Xiaoyi ZHANG
1
;
Zheng KUAI
1
;
Yunzeng ZOU
2
Author Information
1. Department of Geriatrics, Zhongshan Hospital, Fudan University
2. Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institute of Biomedical Sciences, Fudan University
- Publication Type:Journal Article
- Keywords:
Cardiovascular system;
Senium;
β2 microglobulin
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2022;27(4):390-396
- CountryChina
- Language:Chinese
-
Abstract:
β2 microglobulin (β2-MG) is a key component I molecule of the major histocompatibility complex class that assists in the cytotoxic T lymphocyte (CTL) immune response. Serum β2-MG content is dynamically correlated with many diseases. Most studies on β2-MG mainly focus on the pathogenesis of kidney disease, tumor and amyloid fibrils. In recent years, some studies have found that β2-MG is also involved in the adverse prognosis of cardiovascular system, cognitive impairment of aging and antibacterial effects. This paper summarized the domestic and foreign studies on β2-MG in recent years, and proposed the possible role of β2-MG in multi-system human body and its potential application prospect of drug molecular targeting.
