Progress of pharmacotherapy for heart failure
10.12092/j.issn.1009-2501.2022.04.004
- Author:
Juan PENG
1
;
Yunzeng ZOU
1
;
Linlin FAN
2
;
Ranyi LI
2
;
Xiaoyu LI
2
;
Qianzhou LV
2
Author Information
1. Shanghai Institute of Cardiovascular Disease, Department of Cardiology Zhongshan Hospital, Fudan University
2. Department of Pharmacy, Zhongshan Hospital, Fudan University
- Publication Type:Journal Article
- Keywords:
Angiotensin receptor-enkephalase inhibitors;
Finerenone;
Heart failure;
Myocardial myosin activators;
Sodium-glucose cotransporter 2 inhibitors;
Soluble guanoside cyclase agonists
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2022;27(4):373-381
- CountryChina
- Language:Chinese
-
Abstract:
Heart failure is the terminal stage of all kinds of heart diseases. Despite the use of a variety of traditional drug standard treatment, the prognosis is still not ideal, and there is an urgent need for the update and improvement of new drugs and treatment methods. In recent years, angiotensin receptor-enkephalase inhibitors (Sacubitril/Valsartan), sodium-glucose cotransporter 2 inhibitors (SGLT-2i), soluble guanoside cyclase agonists (Vericiguat) and myocardial myosin activators omecamtiv mecarbil have been developed successively. SGLT2 inhibitors can improve ventricular load, reduce fibrosis and affect myocardial metabolism. sGC agonists play an anti-heart failure role by enhancing l-ARg-No-SGC-CGMP signaling pathway, improving myocardial and vascular function, reversing ventricular hypertrophy and fibrosis, slowing ventricular remodeling, and reducing ventricular afterload through systemic and pulmonary vasodilation. In addition, fineridone, a novel salt corticosteroid receptor antagonist, has also been reported in clinical studies in the field of heart failure. Therefore, it is the direction and hope for the development of heart failure in the future to select appropriate drugs for different types of patients with heart failure and carry out individualized treatment according to the optimized process of heart failure.
