Mechanism of vascular endothelial cells ferroptosis in cervical spondylosis of vertebral artery type
10.12092/j.issn.1009-2501.2022.05.012
- Author:
Kai WANG
1
;
Min SONG
1
;
Zhijing SONG
1
;
Jinyi LI
1
;
Min SONG
2
;
Zhijing SONG
2
Author Information
1. Clinical College of Chinese Medicine, Gansu University of Chinese Medicine
2. Department of Orthopedics, the Affiliated Hospital of Gansu University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Cervical spondylosis of vertebral artery type;
Ferroptosis;
Iron homeostasis;
Lipid peroxidation;
Pathomechanisms
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2022;27(5):588-594
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a novel type of cell death, characterized by iron overload and lipid metabolism disorders, and is closely related to the occurrence of cardiovascular and cerebrovascular diseases, tumors, and acute injuries. When tissues and organs of the body are in a state of ischemia and hypoxia, iron ions initiate lipid peroxidation and produce a large number of oxygen free radicals. A series of oxidative stress reactions are more likely to trigger ferroptosis. In the process of cervical spondylosis of vertebral artery type, insufficient blood supply to the vertebral artery caused by degenerative changes of the cervical spine leads to imbalance of iron homeostasis and abnormal amino acid metabolism. Then ferroptosis is induced and plays an important role in the development of cervical spondylosis of vertebral artery type. This paper reviewed the mechanism of ferroptosis in the occurrence of cervical spondylosis of vertebral artery type, in order to provide new ideas and perspectives for the study of related problems of the disease.
