Study on the screening of active constituents of Taohong Siwu Decoction and the protective effect of ferulic acid on myocardial injury

Author: Yizhen LIU ¹ ; Lingxuan REN ¹ ; Jianjun YANG ¹ ; Jianyu HE ¹ ; Rong LIN ¹ ; Xiaojun LIU ² ; Long WANG ²
Author Information

1. Department of Pharmacology, Xi'an Jiaotong University Health Science Center
2. Xi'an Xinrun Pharmaceutical Co., Ltd.
Publication Type:Journal Article
Keywords: Active constituents; Energy metabolism; Ferulic acid; Myocardial injury; Taohong Siwu Decoction
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2022;27(5):505-515
CountryChina
Language:Chinese
Abstract: AIM: To screen the active constituents in Taohong Siwu Decoction(THSWD) by Systems Pharmacology and to study its protective effect on myocardial injury through cell experiments. METHODS: The TCMSP database and Pharmmaper database were used to retrieve the constituents and active constituent targets of THSWD. The Genecards database was used to retrieve the myocardial injury related targets gene. Then construct and analyze the constituents-disease intersection target network and the contribution value of constituents, and screen out the main active constituents of THSWD acting on the myocardium. Furthermore, CoCl