Roles of indoxyl sulfate in complications of chronic kidney disease
10.12092/j.issn.1009-2501.2022.06.011
- Author:
Xinru ZHU
1
;
Xin HUANG
1
;
Xinru ZHU
2
;
Xin HUANG
2
;
Xin HUANG
3
Author Information
1. New Drug Screening Center, Institute of Pharmaceutical Sciences, China Pharmaceutical University
2. Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University
3. Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education
- Publication Type:Journal Article
- Keywords:
chronic kidney disease;
complications of chronic kidney disease;
indoxyl sulfate;
uremic toxin
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2022;27(6):672-679
- CountryChina
- Language:Chinese
-
Abstract:
Chronic kidney disease is a global public health problem, and its occurrence and development are closely related to the exposure of uremic toxins in vivo. Indoxyl sulfate is one of protein-bound enterogenous uremic toxin, it significantly accumulates in patients with chronic kidney disease as renal function declines. Indoxyl sulfate not only promotes the progression of chronic kidney disease, but also induces pathological changes in other tissues and organs, causing complications in other organs related to chronic kidney disease. This article mainly reviews the effect of indoxyl sulfate on blood vessels, muscle, skeleton and brain and their mechanisms, and summarizes chronic kidney disease treatment by clearing indoxyl sulfate.
