Regulatory mechanism of LDLR and research progress of its related diseases and drugs
10.12092/j.issn.1009-2501.2022.08.014
- Author:
Miao LI
1
;
Qinwei YU
1
;
Zhenzhou JIANG
1
;
Luyong ZHANG
1
;
Luyong ZHANG
2
Author Information
1. China Pharmaceutical University, New Drug Screening Center of Institute of Pharmaceutical Sciences
2. Guangdong Pharmaceutical University, New Drug Research and Development Center
- Publication Type:Journal Article
- Keywords:
drug research progress;
LDLR;
LDLR related diseases;
regulation mechanism
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2022;27(8):946-954
- CountryChina
- Language:Chinese
-
Abstract:
Cholesterol is an important lipid component in the body, which not only participates in the formation of cell membranes, but also is the raw material for the synthesis of bile acids and steroid hormones. Low density lipoprotein receptor (LDLR) is involved in cholesterol metabolism and plays an important role in maintaining the cholesterol homeostasis of organism cells. The expression of LDLR is precisely regulated by transcription, post-transcription and post-translation, and the imbalance of ldlr expression will lead to the occurrence and development of many diseases. In this paper, the molecular regulation mechanism of LDLR, the damage of target organs caused by the imbalance of LDLR expression and the research and development progress of drugs targeting LDLR are reviewed, which provides theoretical basis for further understanding of the progress of diseases related to lipid metabolism disorder and new insights for developing drugs targeting LDLR with more effective and less side effects.
