Advances in uridine diphosphate glucuronosyltransferase-mediated drug interactions with tyrosine kinase inhibitors
- Author:
Xueru HE
1
;
Yuhao FU
1
;
Xuejiao XUN
1
;
Yanjun CUI
1
;
Xueru HE
2
;
Yuhao FU
2
;
Xuejiao XUN
2
;
Yanjun CUI
2
;
Zhanjun DONG
2
Author Information
- Publication Type:Journal Article
- Keywords: drug-drug interactions; tyrosine kinase inhibitors; uridine diphosphate glucuronidases
- From: Chinese Journal of Clinical Pharmacology and Therapeutics 2022;27(8):936-945
- CountryChina
- Language:Chinese
- Abstract: Drug-drug interactions (DDI) of tyrosine kinase inhibitors (TKIs) mediated by metabolic enzymes and transporters have become an important issue in clinical practice recently. In addition to CYP450 enzymes, uridine diphosphate glucuronidases (UGTs) are another class of metabolic enzymes involved in the metabolism of TKIs, and most TKIs can inhibit the UGTs in vitro. Potential clinically meaningful DDIs may occur with the co-administration of TKIs and substrates or inhibitors of UGTs. This paper will mainly focus on the UGTs-mediated drug-drug and the effect of UGT1A genotype on the drug interactions of TKIs and explores strategies to address, aiming to provide clinicians and pharmacists with references for the safe and rational application of TKIs.
