Research progress on chemistry and bioactivity of isopentenyl flavonoids from Sophora flavescens

Xudong HE; Zhongyu FU; Jinbiao HE; Xuemei PU; Jie LI; Yanjuan LI; Jie YU; Xingxin Yang; Xudong HE; Zhongyu FU; Ying Huang; Jinbiao HE; Xuemei PU; Jie LI; Yanjuan LI; Jie YU; Xingxin Yang; Ying Huang

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Research progress on chemistry and bioactivity of isopentenyl flavonoids from Sophora flavescens

Author: Xudong HE ¹ ; Zhongyu FU ¹ ; Jinbiao HE ¹ ; Xuemei PU ¹ ; Jie LI ¹ ; Yanjuan LI ¹ ; Jie YU ¹ ; Xingxin YANG ¹ ; Xudong HE ² ; Zhongyu FU ² ; Ying HUANG ² ; Jinbiao HE ² ; Xuemei PU ² ; Jie LI ² ; Yanjuan LI ² ; Jie YU ² ; Xingxin YANG ² ; Ying HUANG ³
Author Information

1. College of Pharmaceutical Science, Yunnan University of Chinese Medicine
2. Yunnan Key Laboratory of Southern Medicine Utilization
3. Yunnan University
Publication Type:Journal Article
Keywords: bioactivity; chemical constituents; isopentenyl flavonoids; sophora flavecens
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2022;27(8):899-907
CountryChina
Language:Chinese
Abstract: Isopentenyl flavonoids are a class of characteristic components in Sophora flavescens Ait. (S. flavescens). They have biological activities such as anti-tumor, anti-bacteria, anti-inflammol/ Lation and anti-oxidation. In this paper, the structural types, toxicology and pharmacological effects of isopentenyl flavonoids from S. flavescens were briefly reviewed. Furthermore, the worth of further study on pharmacokinetics, pharmacodynamics, toxicology, action targets, molecular mechanisms and structure-function relationships of isopentenyl flavonoids were proposed. The deep exploration on functional characterastics of isopentenyl flavonoids of S. flavescens and their application on development of innovative drugs are of great significance to further improve the added value of isopentenyl flavonoids and expand their application fields.