Research progress on experimental pharmacology models of sarcopenia from the view of senescence
10.12092/j.issn.1009-2501.2022.08.008
- Author:
Yongfang FU
1
;
Yixun GUO
1
;
Yan ZHANG
1
;
Jing WANG
2
;
Wenxiong LI
3
;
Yan ZHANG
4
Author Information
1. Longhua Hospital, Shanghai University of Traditional Chinese Medicine
2. Shanghai Geriatric Institute of Chinese Medicine
3. Affiliated Hospital of Shaanxi University of Chinese Medicine
4. Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education
- Publication Type:Journal Article
- Keywords:
pharmacological model;
sarcopenia;
senescence;
skeletal muscle
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2022;27(8):892-898
- CountryChina
- Language:Chinese
-
Abstract:
Sarcopenia, characterized as the progressive decrease in skeletal muscle mass, strength, and function, has been becoming one of chronic musculoskeletal diseases in aging people. In basic research studies, a reliable experimental model would be vital significance for deeply understanding pathophysiological mechanism of sarcopenia and developing novel drugs. This review provided a preliminary summary on the potential mechanisms involved in senescence-induced sarcopenia, followed by a discussion on research progress on pharmacology models based on molecular mechanism of senescence, especially from in vitro cell models and in vivo animal models.
