Effect of COX-2 inhibitors on postoperative delirium in elderly patients undergoing orthopedic surgery and its possible mechanism
10.12092/j.issn.1009-2501.2022.08.004
- Author:
Jinhuo WANG
1
;
Xinyue GAO
1
;
Jianrong GUO
1
Author Information
1. Department of Anesthesiology, Gongli Hospital, Naval Military Medical University
- Publication Type:Journal Article
- Keywords:
COX-2 inhibitor;
HO-1;
oxidative stress;
postoperative delirium
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2022;27(8):863-869
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effects of cyclooxygenase-2 (COX-2) inhibitors on the levels of inflammatory factors, nerve damage-related factors and antioxidant factors, as well as pain and delirium scores in the plasma of elderly patients with orthopaedic surgery, to clarify the role of COX-2 inhibitors in the prevention and treatment of POD and explore its possible mechanism. METHODS: Eighty patients undergoing elective hip arthroplasty were randomly divided into parecoxib sodium group (P group, n =40) and control group (C group, n = 40). Group C was injected with the same volume of normal saline at the same time point, and the preoperative cognitive function was screened 1 d (T
