Research progress on the mechanism of iron overload in the occurrence and development of osteoarthritis
10.12092/j.issn.1009-2501.2022.09.016
- Author:
Liang WANG
1
;
Chaoqiang YANG
1
;
Yican WANG
1
;
Hulin ZHANG
2
;
Xiaomin WANG
2
;
Xueqian LAI
3
Author Information
1. Clinical College of Chinese Medicine, Gansu University of Chinese Medicine
2. Affiliated Hospital of Gansu University of Chinese Medicine (Northern Region)
3. School of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
iron overload;
mechanism;
osteoarthritis
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2022;27(9):1075-1080
- CountryChina
- Language:Chinese
-
Abstract:
Osteoarthritis (OA) is a common chronic degenerative disease, and its condition tends to worsen with age. The pathogenesis of OA is complex, and many risk factors can lead to the occurrence of OA. Iron is one of the essential trace elements in the body, and its metabolic balance is extremely important to human health. Iron overload is closely related to the occurrence and development of OA. Excessive iron deposition in joint tissue can easily lead to lesions of articular cartilage and synovium, as well as affect subchondral bone reconstruction and lead to the occurrence of OA. The author reviewed the relevant research literature in recent years, and reviewed the mechanism of iron overload in the occurrence and development of OA, in order to provide new ideas and directions for the research and diagnosis and treatment of OA.
