New advances in nervous system of lipoprotein lipase
10.12092/j.issn.1009-2501.2022.09.011
- Author:
Yuan LV
1
;
Bin DAI
1
;
Zhonghou LIANG
1
;
Shuzhi WANG
2
Author Information
1. Hunan Engineering Research Center for Applied Technology of Understory Medicinal Plants, Hunan Polytechnic of Environment and Biology
2. University of South China
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
lipoprotein lipase;
nervous system
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2022;27(9):1041-1048
- CountryChina
- Language:Chinese
-
Abstract:
Lipoprotein lipase (LPL) is a key enzyme in lipid and lipoprotein metabolism. LPL mainly hydrolyzes triglyceride-rich lipoproteins and provides free fatty acid (FFAs) for metabolic tissues. LPL acts as a molecular bridge between lipoproteins and cell surface lipoprotein receptors, facilitating lipoprotein uptake. Recent studies have shown that LPL is widely expressed in tissues. LPL has a variety of physiological functions, Lipoprotein lipase (LPL) is a key enzyme in lipid and lipoprotein metabolism. LPL mainly hydrolyzes triglyceride-rich lipoproteins and provides free fatty acid (FFAs) for metabolic tissues. LPL acts as a molecular bridge between lipoproteins and cell surface lipoprotein receptors, facilitating lipoprotein uptake. Recent studies have shown that LPL is widely expressed in tissues. LPL has a variety of physiological functions, which regulates lipid metabolism and energy balance in the brain. Besides, it is closely related to Alzheimer's disease. This paper mainly reviews the latest research progress of LPL in the nervous system and provides new targets for the treatment and prevention.
