Meropenem population pharmacokinetic model for the Chinese elderly established by model-based META analysis
10.12092/j.issn.1009-2501.2022.09.004
- Author:
Hongbo YE
1
;
Yangyang SONG
1
;
Ling XUE
2
;
Jianzhong RUI
3
Author Information
1. Department of Pharmacy, Anji Traditional Chinese Medicine Hospital
2. Department of Clinical Pharmacology, The First Affiliated Hospital of Soochow University
3. Department of Pharmacy, Nanjing General Hospital of PLA
- Publication Type:Journal Article
- Keywords:
meropenem;
model-based meta-analysis;
NONMEM;
the Chinese eldlerly
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2022;27(9):984-990
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To build a meropenem population pharmacokinetic model for Chinese elderly through model-based meta-analysis. METHODS: Informations including dosing regimen, sampling times, concentrations, sample size, age, gender, body weight (BW) and creatinine clearance were extracted after the literature were retrieved. The model was built by NONMEM. Stepwise covariate modeling strategy was used for covariates analysis. RESULTS: A two-compartment model was applied to describe meropenem pharmacokinetics. After stepwise covariate modeling, covariates that remained significant in the final model were creatinine clearance (CLcr) on CL and the BW on V
